Pestilence may refer to:

Infectious disease

Pestilence, one of the Four Horsemen of the Apocalypse

Pestilence (band), a Dutch death metal group

Pestilence (comics), a Marvel Comics supervillain, based on the biblical horseman

"Pestilence" (Medici: Masters of Florence), a television episode

"The Pestilence", a song by Kreator from Pleasure to Kill

"The Pestilence" is another name for the Black Death.