Amoss is a surname. Notable people with the surname include:

David Amoss, American tobacco farmer

Jim Amoss (born 1947), American journalist, former editor of The Times-Picayune

Thomas M. Amoss (born 1961), American thoroughbred horse trainer

Ulius Louis Amoss (1895–1961), American intelligence officer

William H. Amoss (1936–1997), American politician