WZ may refer to:

WZ sex-determination system, also known as the ZW sex-determination system

WZ theory, a technique for simplifying certain combinatorial summations in mathematics

Eswatini (FIPS 10-4 country code WZ)

Westdeutsche Zeitung, a German newspaper

Wetzlar, Germany

WinZip, a computer file compression software

Wizet, a Korean online gaming developer, which uses the file extension .wZ

W and Z bosons in particle physics