Ozuna is a Spanish surname. Notable people with the surname include:

Ozuna (singer) (born 1992), stage name of Juan Carlos Ozuna Rosado, Puerto Rican-Dominican reggaeton and Latin trap singer

Erick Ozuna López (born 1990), Dominican footballer

Marcell Ozuna (born 1990), Dominican baseball outfielder

Pablo Ozuna (born 1974), Dominican baseball utility player

Sunny Ozuna, lead singer of Sunny & the Sunglows

Jorge Radhamés Zorrilla Ozuna (born 1954), Dominican general and politician