Sese or SESE may refer to:

Sese, Botswana, a village in Ngwaketse sub-district, Southern District (Botswana)

Sese coal mine, in Central District, Botswana

Sese Islands, an archipelago in Lake Victoria, Uganda

Sese language, a Niger-Congo language of the Central African Republic and the Democratic Republic of the Congo

Single-entry single-exit, in graph theory

Social, Environmental and Scientific Education, a curriculum for primary school in English-speaking countries; see Greenwave

Southern Exposure Seed Exchange, a seed company in Virginia, United States

Swiss Transportation Safety Investigation Board (Service suisse d'enquête de Securité)

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