OFB may refer to:

Ordnance Factories Board, an Indian industrial setup engaged in the production of arms, ammunition and other equipment for military and civilian applications

Austrian Football Association (German: Österreichischer Fußball-Bund, ÖFB)

Outflow boundary, in meteorology, the leading edge of precipitation-cooled air emanating from a thunderstorm

Output feedback, a mode of operation for block ciphers in cryptography

Overseas Filipino Bank, a state-owned bank in the Philippines

Oklahoma Farm Bureau

Open for Business, an online general interest publication with a technology focus

The Sims 2: Open for Business

Oregon Food Bank

OFB (group), or Original Farm Boys, a UK drill music group