KSM may refer to:

Kernel same-page merging, sharing identical computer memory pages among processes

Khalid Sheikh Mohammed, terrorist held at Guantanamo Bay

Kothagudem School of Mines, later University College of Engineering, Kakatiya University, India

Kommando Spezialkräfte Marine, special forces of the German Navy

Komunistický svaz mládeže or Communist Youth Union, the youth wing of the Communist Party of Bohemia and Moravia

Kerr Sulphurets Mitchell, an active mine exploration project in British Columbia

KSM (band), an American all girl rock band

KPH (radio station), by alternative callsign

St. Mary's Airport (Alaska), by airport code

Kosmos Airlines, by airline code

KSM, a series of microphones by Shure